The M. Sc. Microbiology programme was started at Tribhuvan University in 1990 for the first time in Nepal at the Central Department of Microbiology, Tribhuvan University, Kirtipur. The course structure of the programme was changed in 1999 and revised in 2008 and 2009. However, the course was based on the annual examination system. The course structure of the programme was changed into semester system in 2013.Therefore, this is a revised semester system credit based course curriculum to make it more competitive and research oriented.